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SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
USERS' SCORE
Good
Based on 2 Reviews
8.6
Supplement Facts
Serving Size: 2 Capsules
Amount Per Serving
%DV
Total Carbohydrate
<1 g
<1%†
Calcium (from calcium magnesium phytate)
131 mg
10%
Phosphorus (from calcium magnesium phytate)
192 mg
15%
Magnesium (from calcium magnesium phytate)
40 mg
10%
IP-6 (inositol hexaphosphate) (from calcium magnesium phytate)
800 mg
**
Inositol
220 mg
**
Top Medical Research Studies
9
Myo-inositol reverses EMT effects
Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells.
High relevance to breast cancer
We explored how myo-inositol impacts breast cells, particularly in the context of a process called Epithelial-Mesenchymal Transition (EMT). This process, often triggered by factors like transforming growth factor beta 1 (TGF-β1), leads to changes in cells that can contribute to cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
Read More
8
Inositol delivery targeting breast cancer
Encapsulation of Inositol Hexakisphosphate with Chitosan via Gelation to Facilitate Cellular Delivery and Programmed Cell Death in Human Breast Cancer Cells.
Significant impact on cancer treatment
We explored the role of inositol hexakisphosphate (InsP) in treating breast cancer. Our goal was to find a more effective way for InsP to enter cancerous cells, because its natural negative charge makes it hard for the cells to absorb. To tackle this, we encapsulated InsP in chitosan, a natural polysaccharide, using an ionic gelation technique.
Through various tests, we optimized the ratio of InsP to chitosan and confirmed its successful encapsulation using methods like gel electrophoresis and spectroscopy. The microscopic examination revealed significant changes in the structure after encapsulation.
We observed that the encapsulated InsP made its way into human breast cancer cells, specifically the MCF-7 line, much more effectively than free InsP. This internalization led to the triggering of apoptosis, or programmed cell death, in these cancer cells. The mechanism appeared to involve an increase in reactive oxygen species, which can lead to cell death.
Our findings suggest that using natural compounds like inositol, delivered via a chitosan framework, could offer promising therapeutic avenues for cancer treatment. This approach might help to reduce the severe side effects often seen with synthetic chemotherapy drugs.
Through various tests, we optimized the ratio of InsP to chitosan and confirmed its successful encapsulation using methods like gel electrophoresis and spectroscopy. The microscopic examination revealed significant changes in the structure after encapsulation.
We observed that the encapsulated InsP made its way into human breast cancer cells, specifically the MCF-7 line, much more effectively than free InsP. This internalization led to the triggering of apoptosis, or programmed cell death, in these cancer cells. The mechanism appeared to involve an increase in reactive oxygen species, which can lead to cell death.
Our findings suggest that using natural compounds like inositol, delivered via a chitosan framework, could offer promising therapeutic avenues for cancer treatment. This approach might help to reduce the severe side effects often seen with synthetic chemotherapy drugs.
Read More
Most Useful Reviews
9.5
Supportive for cancer
Very effective against cancer. It worked wonders for my mother in her battle with breast cancer. We also mixed it with black seed oil. Highly recommend.
Read More
8.8
Tumour occurrences decreased
Good for reducing tumour occurrences. I give this to both myself and my dog, who suffers from fatty tumours in old age. I’m unsure about its effects on my dog, but it has certainly worked for my mother with breast cancer.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.5
9
Myo-inositol reverses EMT effects
Myo-Inositol Reverses TGF-β1-Induced EMT in MCF-10A Non-Tumorigenic Breast Cells.
High relevance to breast cancer
We explored how myo-inositol impacts breast cells, particularly in the context of a process called Epithelial-Mesenchymal Transition (EMT). This process, often triggered by factors like transforming growth factor beta 1 (TGF-β1), leads to changes in cells that can contribute to cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
Our study focused on non-tumorigenic MCF-10A breast cells, where we observed a remarkable transformation when these cells were exposed to TGF-β1. The cells lost their usual tight connections and took on a more flexible, mesenchymal shape, which is a hallmark of EMT.
However, when we applied myo-inositol, we saw an impressive reversal of these changes. The presence of myo-inositol helped restore the important cell connection proteins (E-cadherin-β-catenin complexes) and encouraged the re-expression of epithelial markers. This shift not only limited the cells' invasive capabilities but also reduced the release of proteins associated with cancer spread.
Our findings indicate that myo-inositol may offer a promising avenue for improving breast cancer treatment by counteracting the effects of EMT. It's encouraging to think about how this simple compound could play a critical role in fighting cancer progression.
Read More
8
Inositol delivery targeting breast cancer
Encapsulation of Inositol Hexakisphosphate with Chitosan via Gelation to Facilitate Cellular Delivery and Programmed Cell Death in Human Breast Cancer Cells.
Significant impact on cancer treatment
We explored the role of inositol hexakisphosphate (InsP) in treating breast cancer. Our goal was to find a more effective way for InsP to enter cancerous cells, because its natural negative charge makes it hard for the cells to absorb. To tackle this, we encapsulated InsP in chitosan, a natural polysaccharide, using an ionic gelation technique.
Through various tests, we optimized the ratio of InsP to chitosan and confirmed its successful encapsulation using methods like gel electrophoresis and spectroscopy. The microscopic examination revealed significant changes in the structure after encapsulation.
We observed that the encapsulated InsP made its way into human breast cancer cells, specifically the MCF-7 line, much more effectively than free InsP. This internalization led to the triggering of apoptosis, or programmed cell death, in these cancer cells. The mechanism appeared to involve an increase in reactive oxygen species, which can lead to cell death.
Our findings suggest that using natural compounds like inositol, delivered via a chitosan framework, could offer promising therapeutic avenues for cancer treatment. This approach might help to reduce the severe side effects often seen with synthetic chemotherapy drugs.
Through various tests, we optimized the ratio of InsP to chitosan and confirmed its successful encapsulation using methods like gel electrophoresis and spectroscopy. The microscopic examination revealed significant changes in the structure after encapsulation.
We observed that the encapsulated InsP made its way into human breast cancer cells, specifically the MCF-7 line, much more effectively than free InsP. This internalization led to the triggering of apoptosis, or programmed cell death, in these cancer cells. The mechanism appeared to involve an increase in reactive oxygen species, which can lead to cell death.
Our findings suggest that using natural compounds like inositol, delivered via a chitosan framework, could offer promising therapeutic avenues for cancer treatment. This approach might help to reduce the severe side effects often seen with synthetic chemotherapy drugs.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Supportive for cancer
Very effective against cancer. It worked wonders for my mother in her battle with breast cancer. We also mixed it with black seed oil. Highly recommend.
8.8
Tumour occurrences decreased
Good for reducing tumour occurrences. I give this to both myself and my dog, who suffers from fatty tumours in old age. I’m unsure about its effects on my dog, but it has certainly worked for my mother with breast cancer.
